Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib

Proteasome inhibitors have great success for their therapeutic potential against hematologic malignancies. First generation proteasome inhibitor bortezomib induced peripheral neuropathy is considered as a limiting factor in chemotherapy and its second-generation counterpart carfilzomib is associated...

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Detalles Bibliográficos
Autores principales: Jannuzzi, Ayse Tarbin, Arslan, Sema, Yilmaz, Ayse Mine, Sari, Gulce, Beklen, Hande, Méndez, Lucía, Fedorova, Maria, Arga, Kazim Yalcin, Karademir Yilmaz, Betul, Alpertunga, Buket
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115161/
https://www.ncbi.nlm.nih.gov/pubmed/32244176
http://dx.doi.org/10.1016/j.redox.2020.101502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115161/
https://www.ncbi.nlm.nih.gov/pubmed/32244176
http://dx.doi.org/10.1016/j.redox.2020.101502

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