A novel DNA vaccine containing multiple TB-specific epitopes casted in a natural structure (ECANS) confers protective immunity against pulmonary mycobacterial challenge

Epitope-based DNA vaccines designed to induce T cell responses specific for Mycobacterium tuberculosis (M. tb) are being developed as a means of addressing vaccine potency. In this study, we predicted 4 T cell epitopes from ESAT-6, Ag85A/B and CFP-10 antigens and constructed an ECANS (epitopes caste...

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Detalles Bibliográficos
Autores principales: Gao, Haifeng, Yue, Yan, Hu, Linkun, Xu, Wei, Xiong, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115364/
https://www.ncbi.nlm.nih.gov/pubmed/19615961
http://dx.doi.org/10.1016/j.vaccine.2009.06.093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115364/
https://www.ncbi.nlm.nih.gov/pubmed/19615961
http://dx.doi.org/10.1016/j.vaccine.2009.06.093

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