Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues

Drug resistance and emergence of new pathogens highlight the need for developing new therapeutic agents. We focused on 2-oxonicotinonitrile (2-ONN) as derivative of the natural product 2-pyridinone. Herein, we describe the synthesis of 2-ONNs bearing two aryl groups, which we coupled with organohali...

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Detalles Bibliográficos
Autores principales: Abou-Elkhair, Reham A.I., Moustafa, Ahmed H., Haikal, Abdelfattah Z., Ibraheem, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115408/
https://www.ncbi.nlm.nih.gov/pubmed/24486419
http://dx.doi.org/10.1016/j.ejmech.2013.12.055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115408/
https://www.ncbi.nlm.nih.gov/pubmed/24486419
http://dx.doi.org/10.1016/j.ejmech.2013.12.055

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