Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: Design, synthesis, biological evaluation, and docking studies

We report the design and synthesis of a series of dipeptide-type inhibitors with novel P3 scaffolds that display potent inhibitory activity against SARS-CoV 3CL(pro). A docking study involving binding between the dipeptidic lead compound 4 and 3CL(pro) suggested the modification of a structurally fl...

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Detalles Bibliográficos
Autores principales: Thanigaimalai, Pillaiyar, Konno, Sho, Yamamoto, Takehito, Koiwai, Yuji, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Akaji, Kenichi, Chen, Shen-En, Naser-Tavakolian, Aurash, Schön, Arne, Freire, Ernesto, Hayashi, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115411/
https://www.ncbi.nlm.nih.gov/pubmed/23994330
http://dx.doi.org/10.1016/j.ejmech.2013.07.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115411/
https://www.ncbi.nlm.nih.gov/pubmed/23994330
http://dx.doi.org/10.1016/j.ejmech.2013.07.037

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