Enfuvirtide−PEG conjugate: A potent HIV fusion inhibitor with improved pharmacokinetic properties

Enfuvirtide (ENF) is a clinically used peptide drug for the treatment of HIV infections, but its poor pharmacokinetic profile (T(1/2) = 1.5 h in rats) and low aqueous solubility make the therapy expensive and inconvenience. In this study, we present a simple and practical strategy to address these p...

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Detalles Bibliográficos
Autores principales: Cheng, Shuihong, Wang, Yan, Zhang, Zhenxing, Lv, Xun, Gao, George F., Shao, Yiming, Ma, Liying, Li, Xuebing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115413/
https://www.ncbi.nlm.nih.gov/pubmed/27240277
http://dx.doi.org/10.1016/j.ejmech.2016.05.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115413/
https://www.ncbi.nlm.nih.gov/pubmed/27240277
http://dx.doi.org/10.1016/j.ejmech.2016.05.027

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