Discovery of unsymmetrical aromatic disulfides as novel inhibitors of SARS-CoV main protease: Chemical synthesis, biological evaluation, molecular docking and 3D-QSAR study

The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a high rate of mortality. Main protease (M(pro)) of SARS-associated coronavirus (SARS-CoV) is an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. During the co...

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Detalles Bibliográficos
Autores principales: Wang, Li, Bao, Bo-Bo, Song, Guo-Qing, Chen, Cheng, Zhang, Xu-Meng, Lu, Wei, Wang, Zefang, Cai, Yan, Li, Shuang, Fu, Sheng, Song, Fu-Hang, Yang, Haitao, Wang, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115414/
https://www.ncbi.nlm.nih.gov/pubmed/28624700
http://dx.doi.org/10.1016/j.ejmech.2017.05.045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115414/
https://www.ncbi.nlm.nih.gov/pubmed/28624700
http://dx.doi.org/10.1016/j.ejmech.2017.05.045

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