Branched-chain C-cyano pyranonucleosides: Synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

This report describes the total and facile synthesis of 3′-C-cyano & 3′-C-cyano-3′-deoxy pyrimidine pyranonucleosides. Reaction of 3-keto glucoside 1 with sodium cyanide gave the desired precursor 3-C-cyano-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (2). Hydrolysis followed by acetylation led...

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Detalles Bibliográficos
Autores principales: Kiritsis, Christos, Manta, Stella, Parmenopoulou, Vanessa, Balzarini, Jan, Komiotis, Dimitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115479/
https://www.ncbi.nlm.nih.gov/pubmed/21917363
http://dx.doi.org/10.1016/j.ejmech.2011.08.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115479/
https://www.ncbi.nlm.nih.gov/pubmed/21917363
http://dx.doi.org/10.1016/j.ejmech.2011.08.033

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