Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

We report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the indole nucleus. Modifications of this template through Mannich and Friedel-Crafts reactions, coupled with nucleophilic displacement and reductive aminations led to 23 final derivatives, whic...

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Detalles Bibliográficos
Autores principales: Musella, Simona, di Sarno, Veronica, Ciaglia, Tania, Sala, Marina, Spensiero, Antonia, Scala, Maria Carmina, Ostacolo, Carmine, Andrei, Graciela, Balzarini, Jan, Snoeck, Robert, Novellino, Ettore, Campiglia, Pietro, Bertamino, Alessia, Gomez-Monterrey, Isabel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115581/
https://www.ncbi.nlm.nih.gov/pubmed/27639368
http://dx.doi.org/10.1016/j.ejmech.2016.09.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115581/
https://www.ncbi.nlm.nih.gov/pubmed/27639368
http://dx.doi.org/10.1016/j.ejmech.2016.09.014

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