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Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives

Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Their in vivo anticonvulsant screenings were performed by two most adopted seizu...

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Detalles Bibliográficos
Autores principales: Siddiqui, Nadeem, Alam, M. Shamsher, Stables, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115639/
https://www.ncbi.nlm.nih.gov/pubmed/21435751
http://dx.doi.org/10.1016/j.ejmech.2011.03.004