Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase

The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M(pro) with the octapeptide AVLQSGFR reported recently as well as the “Chou's distorted...

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Autores principales: Gan, Yi-Ru, Huang, He, Huang, Yong-Dong, Rao, Chun-Ming, Zhao, Yang, Liu, Jin-Sheng, Wu, Lei, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115688/
https://www.ncbi.nlm.nih.gov/pubmed/16242214
http://dx.doi.org/10.1016/j.peptides.2005.09.006
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author Gan, Yi-Ru
Huang, He
Huang, Yong-Dong
Rao, Chun-Ming
Zhao, Yang
Liu, Jin-Sheng
Wu, Lei
Wei, Dong-Qing
author_facet Gan, Yi-Ru
Huang, He
Huang, Yong-Dong
Rao, Chun-Ming
Zhao, Yang
Liu, Jin-Sheng
Wu, Lei
Wei, Dong-Qing
author_sort Gan, Yi-Ru
collection PubMed
description The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M(pro) with the octapeptide AVLQSGFR reported recently as well as the “Chou's distorted key” theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration.
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spelling pubmed-71156882020-04-02 Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase Gan, Yi-Ru Huang, He Huang, Yong-Dong Rao, Chun-Ming Zhao, Yang Liu, Jin-Sheng Wu, Lei Wei, Dong-Qing Peptides Article The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV M(pro) with the octapeptide AVLQSGFR reported recently as well as the “Chou's distorted key” theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration. Elsevier Inc. 2006-04 2005-10-19 /pmc/articles/PMC7115688/ /pubmed/16242214 http://dx.doi.org/10.1016/j.peptides.2005.09.006 Text en Copyright © 2005 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gan, Yi-Ru
Huang, He
Huang, Yong-Dong
Rao, Chun-Ming
Zhao, Yang
Liu, Jin-Sheng
Wu, Lei
Wei, Dong-Qing
Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title_full Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title_fullStr Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title_full_unstemmed Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title_short Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
title_sort synthesis and activity of an octapeptide inhibitor designed for sars coronavirus main proteinase
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115688/
https://www.ncbi.nlm.nih.gov/pubmed/16242214
http://dx.doi.org/10.1016/j.peptides.2005.09.006
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