Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer’s Disease Drug Discovery

[Image: see text] Transthyretin (TTR) modulates the deposition, processing, and toxicity of Abeta (Aβ) peptides. We have shown that this effect is enhanced in mice by treatment with small molecules such as iododiflunisal (IDIF, 4), a good TTR stabilizer. Here, we describe the thermodynamics of the f...

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Detalles Bibliográficos
Autores principales: Cotrina, Ellen Y., Gimeno, Ana, Llop, Jordi, Jiménez-Barbero, Jesús, Quintana, Jordi, Valencia, Gregorio, Cardoso, Isabel, Prohens, Rafel, Arsequell, Gemma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115756/
https://www.ncbi.nlm.nih.gov/pubmed/32124607
http://dx.doi.org/10.1021/acs.jmedchem.9b01970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115756/
https://www.ncbi.nlm.nih.gov/pubmed/32124607
http://dx.doi.org/10.1021/acs.jmedchem.9b01970

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