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Gain-of-Function Effects of N-Terminal CEBPA Mutations in Acute Myeloid Leukemia
Mutations in the CEBPA gene are present in 10–15% of acute myeloid leukemia (AML) patients. The most frequent type of mutations leads to the expression of an N-terminally truncated variant of the transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα), termed p30. While initial reports pr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115832/ https://www.ncbi.nlm.nih.gov/pubmed/31867767 http://dx.doi.org/10.1002/bies.201900178 |