Gain-of-Function Effects of N-Terminal CEBPA Mutations in Acute Myeloid Leukemia

Mutations in the CEBPA gene are present in 10–15% of acute myeloid leukemia (AML) patients. The most frequent type of mutations leads to the expression of an N-terminally truncated variant of the transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα), termed p30. While initial reports pr...

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Detalles Bibliográficos
Autores principales: Schmidt, Luisa, Heyes, Elizabeth, Grebien, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115832/
https://www.ncbi.nlm.nih.gov/pubmed/31867767
http://dx.doi.org/10.1002/bies.201900178

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