Complexin Suppresses Spontaneous Exocytosis by Capturing the Membrane-Proximal Regions of VAMP2 and SNAP25

The neuronal protein complexin contains multiple domains that exert clamping and facilitatory functions to tune spontaneous and action potential-triggered synaptic release. We address the clamping mechanism and show that the accessory helix of complexin arrests assembly of the soluble N-ethylmaleimi...

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Detalles Bibliográficos
Autores principales: Malsam, Jörg, Bärfuss, Simon, Trimbuch, Thorsten, Zarebidaki, Fereshteh, Sonnen, Andreas F.-P., Wild, Klemens, Scheutzow, Andrea, Rohland, Lukas, Mayer, Matthias P., Sinning, Irmgard, Briggs, John A.G., Rosenmund, Christian, Söllner, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116205/
https://www.ncbi.nlm.nih.gov/pubmed/32698012
http://dx.doi.org/10.1016/j.celrep.2020.107926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116205/
https://www.ncbi.nlm.nih.gov/pubmed/32698012
http://dx.doi.org/10.1016/j.celrep.2020.107926

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