The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer(1,2). Here we studied the effects of hotspot gain-of-function mutations in Trp53 (the gene that encodes p53 in mice) in mouse models of W...

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Detalles Bibliográficos
Autores principales: Kadosh, Eliran, Snir-Alkalay, Irit, Venkatachalam, Avanthika, May, Shahaf, Lasry, Audrey, Elyada, Ela, Zinger, Adar, Shaham, Maya, Vaalani, Gitit, Mernberger, Marco, Stiewe, Thorsten, Pikarsky, Eli, Oren, Moshe, Ben-Neriah, Yinon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116712/
https://www.ncbi.nlm.nih.gov/pubmed/32728212
http://dx.doi.org/10.1038/s41586-020-2541-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116712/
https://www.ncbi.nlm.nih.gov/pubmed/32728212
http://dx.doi.org/10.1038/s41586-020-2541-0

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