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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer(1,2). Here we studied the effects of hotspot gain-of-function mutations in Trp53 (the gene that encodes p53 in mice) in mouse models of W...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116712/ https://www.ncbi.nlm.nih.gov/pubmed/32728212 http://dx.doi.org/10.1038/s41586-020-2541-0 |