Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB

The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels...

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Detalles Bibliográficos
Autores principales: Periyasamy, Manikandan, Singh, Anup K, Gemma, Carolina, Farzan, Raed, Allsopp, Rebecca C, Shaw, Jacqueline A, Charmsaz, Sara, Young, Leonie S, Cunnea, Paula, Coombes, R Charles, Győrffy, Balázs, Buluwela, Lakjaya, Ali, Simak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116738/
https://www.ncbi.nlm.nih.gov/pubmed/33323971
http://dx.doi.org/10.1038/s41388-020-01583-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116738/
https://www.ncbi.nlm.nih.gov/pubmed/33323971
http://dx.doi.org/10.1038/s41388-020-01583-7

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