Ribosomopathy-associated mutations cause proteotoxic stress that is alleviated by TOR inhibition

Ribosomes are multi-component molecular machines that synthesize all the proteins of living cells. Understandably, most genes encoding the protein components of ribosomes are essential. Reduction in gene dosage is often viable but deleterious and associated with human syndromes, collectively known a...

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Detalles Bibliográficos
Autores principales: Recasens-Alvarez, Carles, Alexandre, Cyrille, Kirkpatrick, Joanna, Nojima, Hisashi, Huels, David J., Snijders, Ambrosius P., Vincent, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116740/
https://www.ncbi.nlm.nih.gov/pubmed/33495632
http://dx.doi.org/10.1038/s41556-020-00626-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116740/
https://www.ncbi.nlm.nih.gov/pubmed/33495632
http://dx.doi.org/10.1038/s41556-020-00626-1

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