CD25-T(reg)-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Intratumoral regulatory T cell (Treg) abundance associates with diminished anti-tumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high affinity receptor subunit for IL-2, is a selective target for Treg depletion in mouse and human malignancies; however, anti...

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Detalles Bibliográficos
Autores principales: Solomon, Isabelle, Amann, Maria, Goubier, Anne, Vargas, Frederick Arce, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y., Ghorani, Ehsan, Akarca, Ayse U, Marafioti, Teresa, Śledzińska, Anna, Sunderland, Mariana Werner, Demane, Dafne Franz, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S., Quezada, Sergio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116816/
https://www.ncbi.nlm.nih.gov/pubmed/33644766
http://dx.doi.org/10.1038/s43018-020-00133-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116816/
https://www.ncbi.nlm.nih.gov/pubmed/33644766
http://dx.doi.org/10.1038/s43018-020-00133-0

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