Metabolic control of DNA methylation in naïve pluripotent cells

The naïve epiblast and embryonic stem cells (ESCs) give rise to all cells of the adult. Such developmental plasticity is associated with genome hypomethylation. Here we show that LIF/Stat3 signaling induces genomic hypomethylation via metabolic reconfiguration. Stat3-/- ESCs show decreased alpha-ket...

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Detalles Bibliográficos
Autores principales: Betto, Riccardo M, Diamante, Linda, Perrera, Valentina, Audano, Matteo, Rapelli, Stefania, Lauria, Andrea, Incarnato, Danny, Arboit, Mattia, Pedretti, Silvia, Rigoni, Giovanni, Guerineau, Vincent, Touboul, David, Stirparo, Giuliano Giuseppe, Lohoff, Tim, Boroviak, Thorsten, Grumati, Paolo, Soriano, Maria E, Nichols, Jennifer, Mitro, Nico, Oliviero, Salvatore, Martello, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116828/
https://www.ncbi.nlm.nih.gov/pubmed/33526924
http://dx.doi.org/10.1038/s41588-020-00770-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116828/
https://www.ncbi.nlm.nih.gov/pubmed/33526924
http://dx.doi.org/10.1038/s41588-020-00770-2

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