PolyQ-independent toxicity associated with novel translational products from CAG repeat expansions

Expanded CAG nucleotide repeats are the underlying genetic cause of at least 14 incurable diseases, including Huntington’s disease (HD). The toxicity associated with many CAG repeat expansions is thought to be due to the translation of the CAG repeat to create a polyQ protein, which forms toxic olig...

Descripción completa

Detalles Bibliográficos
Autores principales: Rudich, Paige, Watkins, Simon, Lamitina, Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117740/
https://www.ncbi.nlm.nih.gov/pubmed/32240172
http://dx.doi.org/10.1371/journal.pone.0227464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117740/
https://www.ncbi.nlm.nih.gov/pubmed/32240172
http://dx.doi.org/10.1371/journal.pone.0227464

Ejemplares similares