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The MHCII peptidome of the pancreatic islet identifies key features of autoimmune peptides

The nature of autoantigens that trigger autoimmune diseases has been much discussed, but direct biochemical identification is lacking for most. Addressing this question demands unbiased examination of the self-peptides displayed by a defined autoimmune major histocompatibility complex class II (MHCI...

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Detalles Bibliográficos
Autores principales: Wan, Xiaoxiao, Vomund, Anthony N., Peterson, Orion J., Chervonsky, Alexander V., Lichti, Cheryl F., Unanue, Emil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117798/
https://www.ncbi.nlm.nih.gov/pubmed/32152506
http://dx.doi.org/10.1038/s41590-020-0623-7