Crystal structure of human PLD1 provides insight into activation by PI(4,5)P(2) and RhoA

The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. PLD1 is directly and synergistically regulated by Protein Kinase C, Arf and Rho GTPase...

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Detalles Bibliográficos
Autores principales: Bowling, Forrest Z., Salazar, Christian M., Bell, Justin A., Huq, Tahrima S., Frohman, Michael A., Airola, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117805/
https://www.ncbi.nlm.nih.gov/pubmed/32198492
http://dx.doi.org/10.1038/s41589-020-0499-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117805/
https://www.ncbi.nlm.nih.gov/pubmed/32198492
http://dx.doi.org/10.1038/s41589-020-0499-8

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