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Crystal structure of human PLD1 provides insight into activation by PI(4,5)P(2) and RhoA
The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. PLD1 is directly and synergistically regulated by Protein Kinase C, Arf and Rho GTPase...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117805/ https://www.ncbi.nlm.nih.gov/pubmed/32198492 http://dx.doi.org/10.1038/s41589-020-0499-8 |