Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering

C1 domains are lipid-binding modules that regulate membrane activation of kinases, nucleotide exchange factors, and other C1-containing proteins to trigger signal transduction. Despite annotation of typical C1 domains as diacylglycerol (DAG) and phorbol ester sensors, the function of atypical counte...

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Detalles Bibliográficos
Autores principales: Ware, Timothy B., Franks, Caroline E., Granade, Mitchell E., Zhang, Mingxing, Kim, Kee-Beom, Park, Kwon-Sik, Gahlmann, Andreas, Harris, Thurl E., Hsu, Ku-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117826/
https://www.ncbi.nlm.nih.gov/pubmed/31932721
http://dx.doi.org/10.1038/s41589-019-0445-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117826/
https://www.ncbi.nlm.nih.gov/pubmed/31932721
http://dx.doi.org/10.1038/s41589-019-0445-9

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