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Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes. Yet, how it does so remains poorly understood as we lack tools to di...

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Detalles Bibliográficos
Autores principales: Suresh, Pooja, Long, Alexandra F, Dumont, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117910/
https://www.ncbi.nlm.nih.gov/pubmed/32191206
http://dx.doi.org/10.7554/eLife.53807