Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs rely on population-dependent contributions of many associated alleles, with limited applicability to understudied populations and r...

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Detalles Bibliográficos
Autores principales: Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118071/
https://www.ncbi.nlm.nih.gov/pubmed/32242022
http://dx.doi.org/10.1038/s41467-020-15464-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118071/
https://www.ncbi.nlm.nih.gov/pubmed/32242022
http://dx.doi.org/10.1038/s41467-020-15464-w

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