Pyrazine ring-based Na(+)/H(+) exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

The Na(+)/H(+) exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cance...

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Detalles Bibliográficos
Autores principales: Rolver, Michala G., Elingaard-Larsen, Line O., Andersen, Anne P., Counillon, Laurent, Pedersen, Stine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118118/
https://www.ncbi.nlm.nih.gov/pubmed/32242030
http://dx.doi.org/10.1038/s41598-020-62430-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118118/
https://www.ncbi.nlm.nih.gov/pubmed/32242030
http://dx.doi.org/10.1038/s41598-020-62430-z

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