Cargando…

Pyrazine ring-based Na(+)/H(+) exchanger (NHE) inhibitors potently inhibit cancer cell growth in 3D culture, independent of NHE1

The Na(+)/H(+) exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rolver, Michala G., Elingaard-Larsen, Line O., Andersen, Anne P., Counillon, Laurent, Pedersen, Stine F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118118/ https://www.ncbi.nlm.nih.gov/pubmed/32242030 http://dx.doi.org/10.1038/s41598-020-62430-z

Ejemplares similares

Dynamic Na(+)/H(+) exchanger 1 (NHE1) – calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation
por: Sjøgaard-Frich, Lise M, et al.
Publicado: (2021)

The mammalian Na+/H+ antiporters NHE-1, NHE-2, and NHE-3 are electroneutral and voltage independent, but can couple to an H+ conductance
Publicado: (1995)

Mechanisms of the Regulation of the Intestinal Na(+)/H(+)Exchanger NHE3
por: He, Peijian, et al.
Publicado: (2010)

Na(+)/H(+) exchanger NHE1 and NHE2 have opposite effects on migration velocity in rat gastric surface cells
por: Paehler vor der Nolte, Anja, et al.
Publicado: (2017)

The cleaved FAS ligand activates the Na(+)/H(+) exchanger NHE1 through Akt/ROCK1 to stimulate cell motility
por: Monet, Michael, et al.
Publicado: (2016)

Rainbow Trout (Oncorhynchus mykiss) Na(+)/H(+) Exchangers tNhe3a and tNhe3b Display Unique Inhibitory Profiles Dissimilar from Mammalian NHE Isoforms
por: Blair, Salvatore, et al.
Publicado: (2021)

How Does Our Knowledge on the Na(+)/H(+) Exchanger NHE1 Obtained by Biochemical and Molecular Analyses Keep up With Its Recent Structure Determination?
por: Poet, Mallorie, et al.
Publicado: (2022)

The Na(+)/H(+) exchanger NHE1 is required for directional migration stimulated via PDGFR-α in the primary cilium
por: Schneider, Linda, et al.
Publicado: (2009)

Expression profile of genes regulated by activity of the Na-H exchanger NHE1
por: Putney, Luanna K, et al.
Publicado: (2004)

Role of the Na(+)/H(+) exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines
por: Li, Xiao C, et al.
Publicado: (2015)

Genes for endosomal NHE6 and NHE9 are misregulated in autism brains
por: Schwede, M, et al.
Publicado: (2014)

Endosomal Na(+)/H(+) exchanger NHE5 influences MET recycling and cell migration
por: Fan, Steven Hung-Yi, et al.
Publicado: (2016)

Metformin Inhibits Na(+)/H(+) Exchanger NHE3 Resulting in Intestinal Water Loss
por: Han, Yiran, et al.
Publicado: (2022)

Complex Formation between NheB and NheC Is Necessary to Induce Cytotoxic Activity by the Three-Component Bacillus cereus Nhe Enterotoxin
por: Heilkenbrinker, Uta, et al.
Publicado: (2013)

Inhibition and Redistribution of NHE3, the Apical Na(+)/H(+) Exchanger, by Clostridium difficile Toxin B
por: Hayashi, Hisayoshi, et al.
Publicado: (2004)

Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function
por: Ganash, Magdah, et al.
Publicado: (2013)

Role of NHE1 in Nociception
por: Torres-López, Jorge Elías, et al.
Publicado: (2013)

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
por: Denker, Sheryl P., et al.
Publicado: (2002)

Loss of the NHE2 Na(+)/H(+) Exchanger in Mice Results in Dilation of Folliculo-Stellate Cell Canaliculi
por: Miller, Marian L., et al.
Publicado: (2011)

Phosphorylation and Activation of the Plasma Membrane Na(+)/H(+) Exchanger (NHE1) during Osmotic Cell Shrinkage
por: Rigor, Robert R., et al.
Publicado: (2011)

Translocation of the Na(+)/H(+) exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling
por: Lawrence, Scott P., et al.
Publicado: (2010)

Endothelial Na(+)/H(+) exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal
por: Qadri, Syed M, et al.
Publicado: (2014)

Endosomal pH in neuronal signaling and synaptic transmission: role of Na(+)/H(+) exchanger NHE5
por: Diering, Graham H., et al.
Publicado: (2014)

The Na(+)/H(+) Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation
por: Babich, Victor, et al.
Publicado: (2015)

Structure and elevator mechanism of the mammalian sodium/proton exchanger NHE9
por: Winklemann, Iven, et al.
Publicado: (2020)

Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes
por: Sarker, Rafiquel, et al.
Publicado: (2017)

Proximal tubule specific knockout of the Na(+)/H(+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
por: Li, Hong C., et al.
Publicado: (2013)

Role of the Basolateral Na(+)/H(+) Exchanger-2 (NHE2) in Ionocytes of Seawater- Acclimated Medaka (Oryzias latipes)
por: Liu, Sian-Tai, et al.
Publicado: (2022)

The Physiological Function and Potential Role of the Ubiquitous Na(+)/H(+) Exchanger Isoform 8 (NHE8): An Overview Data
por: Bernardazzi, Claudio, et al.
Publicado: (2022)

The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function
por: Lawrence, Scott P., et al.
Publicado: (2010)

Ezrin Is Required for the Functional Regulation of the Epithelial Sodium Proton Exchanger, NHE3
por: Hayashi, Hisayoshi, et al.
Publicado: (2013)

Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na(+)/H(+) exchanger NHE5
por: Diering, Graham H., et al.
Publicado: (2011)

Glucocorticoids reduce renal NHE8 expression
por: Joseph, Catherine, et al.
Publicado: (2013)

Myocardial Impact of NHE1 Regulation by Sildenafil
por: Escudero, Daiana S., et al.
Publicado: (2021)

Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway
por: Peng, Shuang, et al.
Publicado: (2023)

The sodium proton exchanger NHE9 regulates phagosome maturation and bactericidal activity in macrophages
por: Shamroukh, Habiba S., et al.
Publicado: (2022)

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons
por: Fernandez, Marty A., et al.
Publicado: (2022)

Positive feedback between Cdc42 activity and H(+) efflux by the Na-H exchanger NHE1 for polarity of migrating cells
por: Frantz, Christian, et al.
Publicado: (2007)

Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na(+)/H(+) exchanger NHE3 by glucocorticoids
por: He, Peijian, et al.
Publicado: (2011)

Expression of Actin-interacting Protein 1 Suppresses Impaired Chemotaxis of Dictyostelium Cells Lacking the Na(+)-H(+) Exchanger NHE1
por: Choi, Chang-Hoon, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ie9m1skeplus114oada9kek86h