Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α(5)β(1) integrin towards choleresis

Functional selectivity is the ligand-specific activation of certain signal transduction pathways at a receptor and has been described for G protein-coupled receptors. However, it has not yet been described for ligands interacting with integrins without αI domain. Here, we show by molecular dynamics...

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Detalles Bibliográficos
Autores principales: Bonus, Michele, Sommerfeld, Annika, Qvartskhava, Natalia, Görg, Boris, Ludwig, Beatrice Stefanie, Kessler, Horst, Gohlke, Holger, Häussinger, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118123/
https://www.ncbi.nlm.nih.gov/pubmed/32242141
http://dx.doi.org/10.1038/s41598-020-62326-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118123/
https://www.ncbi.nlm.nih.gov/pubmed/32242141
http://dx.doi.org/10.1038/s41598-020-62326-y

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