Dual functions of Aire CARD multimerization in the transcriptional regulation of T cell tolerance

Aggregate-like biomolecular assemblies are emerging as new conformational states with functionality. Aire, a transcription factor essential for central T cell tolerance, forms large aggregate-like assemblies visualized as nuclear foci. Here we demonstrate that Aire utilizes its caspase activation re...

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Detalles Bibliográficos
Autores principales: Huoh, Yu-San, Wu, Bin, Park, Sehoon, Yang, Darren, Bansal, Kushagra, Greenwald, Emily, Wong, Wesley P., Mathis, Diane, Hur, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118133/
https://www.ncbi.nlm.nih.gov/pubmed/32242017
http://dx.doi.org/10.1038/s41467-020-15448-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118133/
https://www.ncbi.nlm.nih.gov/pubmed/32242017
http://dx.doi.org/10.1038/s41467-020-15448-w

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