Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes

High-grade serous ovarian carcinoma (HGSOC) has a significant hereditary component, approximately half of which cannot be explained by known genes. To discover genes, we analyse germline exome sequencing data from 516 BRCA1/2-negative women with HGSOC, focusing on genes enriched with rare, protein-c...

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Detalles Bibliográficos
Autores principales: Subramanian, Deepak N., Zethoven, Magnus, McInerny, Simone, Morgan, James A., Rowley, Simone M., Lee, Jue Er Amanda, Li, Na, Gorringe, Kylie L., James, Paul A., Campbell, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118163/
https://www.ncbi.nlm.nih.gov/pubmed/32242007
http://dx.doi.org/10.1038/s41467-020-15461-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118163/
https://www.ncbi.nlm.nih.gov/pubmed/32242007
http://dx.doi.org/10.1038/s41467-020-15461-z

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