Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles

A chemical library comprising 2,354 drug-like compounds was screened using a transcription and replication-competent virus-like particle (trVLP) system implementing the whole Ebola virus (EBOV) life cycle. Dose-dependent inhibition of Ebola trVLP replication was induced by 15 hit compounds, which pr...

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Detalles Bibliográficos
Autores principales: Yoon, Yi-Seul, Jang, Yejin, Hoenen, Thomas, Shin, Heegwon, Lee, Younghoon, Kim, Meehyein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118351/
https://www.ncbi.nlm.nih.gov/pubmed/31964466
http://dx.doi.org/10.5483/BMBRep.2020.53.3.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118351/
https://www.ncbi.nlm.nih.gov/pubmed/31964466
http://dx.doi.org/10.5483/BMBRep.2020.53.3.175

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