Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

Ebola virus causes severe hemorrhagic fever, often leading to death in humans. The trimeric fusion glycoprotein (GP) is the sole target for neutralizing antibodies and is the major focus of vaccine development. Soluble GP ectodomains are unstable and mostly monomeric when not fused to a heterologous...

Descripción completa

Detalles Bibliográficos
Autores principales: Rutten, Lucy, Gilman, Morgan S.A., Blokland, Sven, Juraszek, Jarek, McLellan, Jason S., Langedijk, Johannes P.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118701/
https://www.ncbi.nlm.nih.gov/pubmed/32234486
http://dx.doi.org/10.1016/j.celrep.2020.03.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118701/
https://www.ncbi.nlm.nih.gov/pubmed/32234486
http://dx.doi.org/10.1016/j.celrep.2020.03.025

Ejemplares similares