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Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
Ebola virus causes severe hemorrhagic fever, often leading to death in humans. The trimeric fusion glycoprotein (GP) is the sole target for neutralizing antibodies and is the major focus of vaccine development. Soluble GP ectodomains are unstable and mostly monomeric when not fused to a heterologous...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Author(s).
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118701/ https://www.ncbi.nlm.nih.gov/pubmed/32234486 http://dx.doi.org/10.1016/j.celrep.2020.03.025 |