Dual Modes of Modification of Hepatitis A Virus 3C Protease by a Serine-derived β-Lactone: Selective Crystallization and Formation of a Functional Catalytic Triad in the Active Site

Hepatitis A virus (HAV) 3C proteinase is a member of the picornain cysteine proteases responsible for the processing of the viral polyprotein, a function essential for viral maturation and infectivity. This and its structural similarity to other 3C and 3C-like proteases make it an attractive target...

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Detalles Bibliográficos
Autores principales: Yin, Jiang, Bergmann, Ernst M., Cherney, Maia M., Lall, Manjinder S., Jain, Rajendra P., Vederas, John C., James, Michael N.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118759/
https://www.ncbi.nlm.nih.gov/pubmed/16288920
http://dx.doi.org/10.1016/j.jmb.2005.09.074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118759/
https://www.ncbi.nlm.nih.gov/pubmed/16288920
http://dx.doi.org/10.1016/j.jmb.2005.09.074

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