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Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition

The secretory pathway in cells possesses an elaborate set of endoproteolytic enzymes that carry out a crucial step in protein precursor maturation. This step is proteolytic activation by cleavage at specific pairs of basic residues. These enzymes, named pro-protein convertases (PCs), are responsible...

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Detalles Bibliográficos
Autores principales: Fugère, Martin, Day, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119077/
https://www.ncbi.nlm.nih.gov/pubmed/15925704
http://dx.doi.org/10.1016/j.tips.2005.04.006