GLI3: a mediator of genetic diseases, development and cancer

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH activation, GLI3-FL regulates HH genes by targeting the GLI1 promoter. In the absence of HH signaling, GLI3 is ph...

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Detalles Bibliográficos
Autores principales: Matissek, Stephan J., Elsawa, Sherine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119169/
https://www.ncbi.nlm.nih.gov/pubmed/32245491
http://dx.doi.org/10.1186/s12964-020-00540-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119169/
https://www.ncbi.nlm.nih.gov/pubmed/32245491
http://dx.doi.org/10.1186/s12964-020-00540-x

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