Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes

MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using...

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Autores principales: Feng, Yin, Shu, Jing, Yao, Liangzhong, Lan, Yutao, Ye, Lianbao, Mei, Wenjie, Ding, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119291/
https://www.ncbi.nlm.nih.gov/pubmed/32266333
http://dx.doi.org/10.1186/s13065-020-00672-8
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author Feng, Yin
Shu, Jing
Yao, Liangzhong
Lan, Yutao
Ye, Lianbao
Mei, Wenjie
Ding, Ying
author_facet Feng, Yin
Shu, Jing
Yao, Liangzhong
Lan, Yutao
Ye, Lianbao
Mei, Wenjie
Ding, Ying
author_sort Feng, Yin
collection PubMed
description MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using microwave-assisted synthetic technology. The isomers can recognize and stabilize miR-21, with the Λ-isomer showing a stronger binding capacity than the Δ-isomer. Further studies showed that both isomers can be uptaken by MDA-MB-231 cells and enriched in the nucleus. Treatment with the Λ-/Δ-isomer downregulated the expression of miR-21. In a word, the development of chiral ruthenium(II) complexes act as potential inhibitors against tumor cells by recognizing, stabilizing, and regulating the expression of miR-21.
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spelling pubmed-71192912020-04-07 Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes Feng, Yin Shu, Jing Yao, Liangzhong Lan, Yutao Ye, Lianbao Mei, Wenjie Ding, Ying BMC Chem Research Article MiR-21, a non-coding miRNA with 22 nucleotides, plays an important part in the proliferation, invasion, and metastasis of tumor cells. The present study demonstrates that isomers of chiral ruthenium(II) complexes with alkynes (Λ-1 and Δ-1) were synthesized by Songogashira coupling reaction by using microwave-assisted synthetic technology. The isomers can recognize and stabilize miR-21, with the Λ-isomer showing a stronger binding capacity than the Δ-isomer. Further studies showed that both isomers can be uptaken by MDA-MB-231 cells and enriched in the nucleus. Treatment with the Λ-/Δ-isomer downregulated the expression of miR-21. In a word, the development of chiral ruthenium(II) complexes act as potential inhibitors against tumor cells by recognizing, stabilizing, and regulating the expression of miR-21. Springer International Publishing 2020-04-03 /pmc/articles/PMC7119291/ /pubmed/32266333 http://dx.doi.org/10.1186/s13065-020-00672-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Feng, Yin
Shu, Jing
Yao, Liangzhong
Lan, Yutao
Ye, Lianbao
Mei, Wenjie
Ding, Ying
Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title_full Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title_fullStr Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title_full_unstemmed Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title_short Recognizing and stabilizing miR-21 by chiral ruthenium(II) complexes
title_sort recognizing and stabilizing mir-21 by chiral ruthenium(ii) complexes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119291/
https://www.ncbi.nlm.nih.gov/pubmed/32266333
http://dx.doi.org/10.1186/s13065-020-00672-8
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