Cargando…

RNA-Sequencing, Connectivity Mapping, and Molecular Docking to Investigate Ligand-Protein Binding for Potential Drug Candidates for the Treatment of Wilms Tumor

BACKGROUND: Wilms tumor, or nephroblastoma, is a malignant pediatric embryonal renal tumor that has a poor prognosis. This study aimed to use bioinformatics data, RNA-sequencing, connectivity mapping, molecular docking, and ligand-protein binding to identify potential targets for drug therapy in Wil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Jia-Yuan, Yan, Shi-Bai, Chen, Gang, Chen, Peng, Liang, Song-Wu, Xu, Qiong-Qian, Gu, Jin-Han, Huang, Zhi-Guang, Qin, Li-Ting, Lu, Hui-Ping, Mo, Wei-Jia, Luo, Yi-Ge, Chen, Jia-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Database Analysis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119447/ https://www.ncbi.nlm.nih.gov/pubmed/32214060 http://dx.doi.org/10.12659/MSM.920725

Ejemplares similares

Network Pharmacology Integrated Molecular Docking Revealed the Mechanism of Jianpi Yiqi Taohua Decoction Against Ulcerative Colitis
por: Jia, Lin, et al.
Publicado: (2022)

Bioinformatics Identification of Candidate Biomarkers in Endomyocardial Biopsy and Peripheral Blood for Cardiac Allograft Rejection
por: Luo, Kang, et al.
Publicado: (2022)

Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (−)-Guaiol Against Lung Adenocarcinoma
por: Zeng, Yaoying, et al.
Publicado: (2022)

Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology
por: Zheng, Chen, et al.
Publicado: (2022)

Emerging Trends and Hot Topics in Cardiopulmonary Resuscitation Research: A Bibliometric Analysis from 2010 to 2019
por: Jia, Tianyuan, et al.
Publicado: (2020)

Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Coronavirus Infection
por: Ping, Fan, et al.
Publicado: (2022)

Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data
por: Zhang, Xinxin, et al.
Publicado: (2020)

Construction and Validation of a 7-Immune Gene Model for Prognostic Assessment of Esophageal Carcinoma
por: Chen, Haitao, et al.
Publicado: (2020)

Small Nucleolar RNAs (snoRNAs)-Based Risk Score Classifier Predicts Overall Survival in Bladder Carcinoma
por: He, Rong-Quan, et al.
Publicado: (2020)

Comprehensive Analysis of Tripterine Anti-Ovarian Cancer Effects Using Weighted Gene Co-Expression Network Analysis and Molecular Docking
por: Long, Xi, et al.
Publicado: (2022)

Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular docking
por: Chen, Yu-Ting, et al.
Publicado: (2018)

Global Research Trends and Hotspots in Lateral Epicondylitis During the Past 30 Years: A Bibliometric and Visualization Study
por: Xu, Jie, et al.
Publicado: (2023)

H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro
por: Luo, Min, et al.
Publicado: (2021)

Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach
por: Song, Shuang, et al.
Publicado: (2020)

Functional Analysis of Estrogen Receptor 1 in Diabetic Wound Healing: A Knockdown Cell-Based and Bioinformatic Study
por: Qi, Sha, et al.
Publicado: (2020)

Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients
por: Dai, Wenjuan, et al.
Publicado: (2020)

Multi-Omics Analysis Reveals the Pan-Cancer Landscape of Bone Morphogenetic Proteins
por: Luo, Wen-Li, et al.
Publicado: (2020)

Construction of Decision Trees Based on Gene Expression Omnibus Data to Classify Bladder Cancer and Its Subtypes
por: Zhou, Jia-Quan, et al.
Publicado: (2021)

A Novel Predictive Model Incorporating Ferroptosis-Related Gene Signatures for Overall Survival in Patients with Lung Adenocarcinoma
por: Wang, Yuli, et al.
Publicado: (2022)

Relationship Between C-Reactive Protein and Respiratory Diseases in Patients with Type 2 Diabetic Retinopathy
por: Chen, Kejia, et al.
Publicado: (2022)

Identification of an Immune Score-Based Gene Panel with Prognostic Power for Oral Squamous Cell Carcinoma
por: Huang, Su-Ning, et al.
Publicado: (2020)

Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis
por: Li, Zongjin, et al.
Publicado: (2020)

Effect of Clemastine Fumarate on Perioperative Hemodynamic Instability Mediated by Anaphylaxis During Cardiopulmonary Bypass Surgery
por: Tian, Lijuan, et al.
Publicado: (2022)

Special AT-rich Sequence Binding-Protein 1 (SATB1) Correlates with Immune Infiltration in Breast, Head and Neck, and Prostate Cancer
por: Ge, Hua, et al.
Publicado: (2020)

Prediction of MiR-21-5p in Promoting the Development of Lung Adenocarcinoma via PDZD2 Regulation
por: Cui, Shengjin, et al.
Publicado: (2020)

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016
por: Zhou, Yue-xi, et al.
Publicado: (2020)

Identification of Potential Prognostic and Predictive Biomarkers for Immune-Checkpoint Inhibitor Response in Small Cell Lung Cancer
por: Gao, Chanchan, et al.
Publicado: (2021)

Rice-Map: a new-generation rice genome browser
por: Wang, Jun, et al.
Publicado: (2011)

Evaluation of Structural Neural Connectivity Between the Primary Auditory Cortex and Cognition-Related Brain Areas Using Diffusion Tensor Tractography in 43 Normal Adults
por: Jang, Sung Ho, et al.
Publicado: (2022)

Unveiling the Hidden Burden: Mapping the Landscape of Post-Intensive Care Syndrome Research. A Bibliometric Study and Visualization Analysis
por: Li, Xiayahu, et al.
Publicado: (2023)

Prediction of Patient Survival with Psoas Muscle Density Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Cohort Study
por: Zhang, Biyu, et al.
Publicado: (2022)

Bioinformatic Profiling of Prognosis-Related Genes in Malignant Glioma Microenvironment
por: Li, Yong, et al.
Publicado: (2020)

The Prognostic Role of Glutathione Peroxidase 1 and Immune Infiltrates in Glioma Investigated Using Public Datasets
por: Lv, Shigang, et al.
Publicado: (2020)

Prognostic Value of E2F Transcription Factor Expression in Pancreatic Adenocarcinoma
por: Luo, Lin, et al.
Publicado: (2021)

Impact of Post-Mastectomy Radiation Therapy for Sentinel Lymph Node Micrometastases in Early-Stage Breast Cancer Patients
por: Luo, Hua, et al.
Publicado: (2022)

Effects of Marital Status on Prognosis in Women with Infiltrating Ductal Carcinoma of the Breast: A Real-World 1: 1 Propensity-Matched Study
por: Lan, Tian, et al.
Publicado: (2020)

Expression and Prognostic Significance of Cadherin 4 (CDH4) in Renal Cell Carcinoma
por: Zhou, Xiaohui, et al.
Publicado: (2020)

Clinicopathological Characteristics and Prognosis of Nasopharyngeal Lymphoepithelial Carcinoma: A Population-Based Retrospective Study
por: Xizhi, Liu, et al.
Publicado: (2020)

Relationships Between Obstructive Sleep Apnea and Cardiovascular Disease: A Bibliometric Analysis (2010–2021)
por: Wang, Yumeng, et al.
Publicado: (2022)

Novel Prognostic Model for Gastric Cancer using 13 Co-Expression Long Non-Coding RNAs (LncRNAs)
por: Luo, Xi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_o3knq8qrbhqk9i0k6ptd5ibsfg