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Gene optimization leads to robust expression of human respiratory syncytial virus nucleoprotein and phosphoprotein in human cells and induction of humoral immunity in mice

Human respiratory syncytial virus (HRSV) is the major pathogen leading to respiratory disease in infants and neonates worldwide. An effective vaccine has not yet been developed against this virus, despite considerable efforts in basic and clinical research. HRSV replication is independent of the nuc...

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Detalles Bibliográficos
Autores principales: Simabuco, Fernando M., Tamura, Rodrigo E., Carromeu, Cassiano, Farinha-Arcieri, Luis E., Ventura, Armando M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119700/
https://www.ncbi.nlm.nih.gov/pubmed/19428575
http://dx.doi.org/10.1016/j.jviromet.2009.01.024