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Proteolytic Processing of Filovirus Glycoproteins

Filoviruses (Marburg virus and Ebola virus) have a single envelope glycoprotein (GP) that initiates infection. GP is a class I fusion protein that forms trimeric spikes composed of heterodimers of the subunits GP1 and GP2. GP1 and GP2 are derived from the precursor pre-GP by furin cleavage during ex...

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Detalles Bibliográficos
Autores principales: Volchkov, Viktor, Klenk, Hans Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122482/
http://dx.doi.org/10.1007/978-3-319-75474-1_5