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Discovery of Beclabuvir: A Potent Allosteric Inhibitor of the Hepatitis C Virus Polymerase
The discovery of beclabuvir occurred through an iterative series of structure-activity relationship studies directed at the optimization of a novel class of indolobenzazepines. Within this research, a strategic decision to abandon a highly potent but physiochemically problematic series in favor of o...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123187/ http://dx.doi.org/10.1007/7355_2018_38 |