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A 16-Step Synthesis of the Isoryanodane Diterpene (+)-Perseanol

(+)-Perseanol is an isoryanodane diterpene with potent antifeedant and insecticidal properties isolated from the tropical shrub Persea indica.(1) It is structurally related to (+)-ryanodine, a high affinity ligand and modulator of ryanodine receptors (RyRs)—ligand-gated ion channels critical for int...

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Detalles Bibliográficos
Autores principales: Han, Arthur, Tao, Yujia, Reisman, Sarah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123484/
https://www.ncbi.nlm.nih.gov/pubmed/31554978
http://dx.doi.org/10.1038/s41586-019-1580-x