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Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function

Cell-specific alternative splicing modulates myriad cell functions and is disrupted in disease. The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic Ca(V...

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Detalles Bibliográficos
Autores principales: López Soto, Eduardo Javier, Lipscombe, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124252/
https://www.ncbi.nlm.nih.gov/pubmed/32213287
http://dx.doi.org/10.7554/eLife.54879