Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

C9ORF72-associated Motor Neuron Disease patients feature abnormal expression of 5 dipeptide repeat (DPR) polymers. Here we used quantitative proteomics in a mouse neuronal-like cell line (Neuro2a) to demonstrate that the Arg residues in the most toxic DPRS, PR and GR, leads to a promiscuous binding...

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Detalles Bibliográficos
Autores principales: Radwan, Mona, Ang, Ching-Seng, Ormsby, Angelique R., Cox, Dezerae, Daly, James C., Reid, Gavin E., Hatters, Danny M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124463/
https://www.ncbi.nlm.nih.gov/pubmed/32086375
http://dx.doi.org/10.1074/mcp.RA119.001888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124463/
https://www.ncbi.nlm.nih.gov/pubmed/32086375
http://dx.doi.org/10.1074/mcp.RA119.001888

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