Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

Transient tunnels that assemble and disassemble to facilitate passage of unstable intermediates in enzymes containing multiple reaction centers are controlled by allosteric cues. Using the 140-kDa purine biosynthetic enzyme PurL as a model system and a combination of biochemical and x-ray crystallog...

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Detalles Bibliográficos
Autores principales: Sharma, Nandini, Ahalawat, Navjeet, Sandhu, Padmani, Strauss, Erick, Mondal, Jagannath, Anand, Ruchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124931/
https://www.ncbi.nlm.nih.gov/pubmed/32284973
http://dx.doi.org/10.1126/sciadv.aay7919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124931/
https://www.ncbi.nlm.nih.gov/pubmed/32284973
http://dx.doi.org/10.1126/sciadv.aay7919

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