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Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation
Transient tunnels that assemble and disassemble to facilitate passage of unstable intermediates in enzymes containing multiple reaction centers are controlled by allosteric cues. Using the 140-kDa purine biosynthetic enzyme PurL as a model system and a combination of biochemical and x-ray crystallog...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124931/ https://www.ncbi.nlm.nih.gov/pubmed/32284973 http://dx.doi.org/10.1126/sciadv.aay7919 |