The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the HCM-causing mutation R663H cannot be explained by changes in fundamental myosin contr...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarkar, Saswata S., Trivedi, Darshan V., Morck, Makenna M., Adhikari, Arjun S., Pasha, Shaik N., Ruppel, Kathleen M., Spudich, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124958/
https://www.ncbi.nlm.nih.gov/pubmed/32284968
http://dx.doi.org/10.1126/sciadv.aax0069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124958/
https://www.ncbi.nlm.nih.gov/pubmed/32284968
http://dx.doi.org/10.1126/sciadv.aax0069

Ejemplares similares