Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe(−/−) Mice

OBJECTIVE: Increased myelopoiesis has been linked to risk of atherosclerotic cardiovascular disease (ACD). Excessive myelopoiesis can be driven by dyslipidemia and cholesterol accumulation in hematopoietic stem and progenitor cells (HSPC) and may involve increased signaling via Janus kinase 2 (JAK2)...

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Detalles Bibliográficos
Autores principales: Tang, Yang, Liu, Wenli, Wang, Wei, Fidler, Trevor, Woods, Britany, Levine, Ross L., Tall, Alan R., Wang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125070/
https://www.ncbi.nlm.nih.gov/pubmed/32086626
http://dx.doi.org/10.1007/s10557-020-06943-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125070/
https://www.ncbi.nlm.nih.gov/pubmed/32086626
http://dx.doi.org/10.1007/s10557-020-06943-9

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